EFFECT OF DAURICINE ON PLATELET AGGREGATION IN RABBITS / 西安交通大学学报(医学版)

ABSTRACT

It has been shown that dauricine possesses antiarrhymic and hypotensive actions. Our experimentation demonstrates that dauricine inhidits platelet aggregation induced by the threshold concentration of adenosine diphosphate (ADP), arachidonic acid (AA) and collagen (Coll) in the dose-dependent way in vitro in rabbits. The aggregatipn inhibition rates produced by dauri- cine 0.08 mg/ml for ADP, AA and Coll are 49.20%, 62.26% and 65.75% respectively. The adnimistration of dauricine 10 mg/kg to the rabbits intravenously also inhibits the platelet aggregation induced by the threshold concentration of ADP, AA and Coll, the aggregation inhibition rates being 40.12%, 32.71% and 21.21% respectively. The results show that the action mechanism of dauricine might be related to Ca-antagonism.