EFFECTS OF SINOMENINE ON ISOLATED GUINEA-PIG AURICLE / 西安交通大学学报(医学版)

ABSTRACT

After Sinomenine 27 ?M was given, the contractibility was decreased to 51?11% (SD) and dT/dt max to 50?14% (SD). The automaticity induced by epinephrine was inhibited. Sinomenine (2.7-270 ?M) caused a concentration-dependent prolongation in the functional period. The amplitude of contraction and the heart rate in the right auricle was also inhibited. The results indicate that sinomenine may be antogonistic to both Ca~(++) influx and inward Na~(++) current.