A TEST OF TRANSFORMING NITRATE WITH HUMAN FUNGI AND SIGNIFICANCE IN MEDICINE / 西安交通大学学报(医学版)

ABSTRACT

We performed the transforming nitrate test mainly with penicillium brevi-compactum and other fungi. The strain of P. brevi-compactum and all the other fungi used for this test were isolated from patients with cervix uteri carcinoma, patients with gynopathy but no cancer, and the normal woman controls in Luoyang county of Shaanxi and in Wufeng county of Hubei respectively, which are the highest prevalance areas of cervix uteri carcinoma in China. The detection rate of P. brevicompactum is higher 72.73% (65/77) in Luoyang; 67.65 (23/34) in Wufeng. The detection rate of yeast and Candida is low. Though the detection rate of certain tested fungi such as A. serreus, A. candidus, P. cyelopium and Rhodotorula rubra is higher, these fungi are seldom found in the isolates from cervix uteri. Thus, these fungi might be no important significance in etiology of cervix uteri carcinoma. Because nitriamine is an important carcinogen and the effect of transforming nitrate to nitrite plays a more important role in the synthesis of nitriamine, P. brevi-compactum is the dominant strain of fungi isolated from the patient with cervix uteri carcinoma in this investigation. The higher detection rate of the treated P. brevi-compactum shows that this fungus plays a role in the etiology or incidence of cervis uteri carcinoma. To solve this difficult and complex problem of the role that fungal agent okay in the etiology of carcinoma further studies must be done.