CD3 McAb Regulates human fetal thymocyte proliferative response to PHA or TPA / 中国免疫学杂志

ABSTRACT

The regulatory effect of CD3 McAb on the human fetal thymocyte proliferative response toTPA was investigated.It was shown that the CD3 McAb couldn't induce human fetal thymo-cyte proliferative response,but suppressed PHA-induced human fetal thymocyte proliferativeresponse and promoted TPA-induced proliferative response,in a dose dependent manner.Ex-ogenous rHuIL—2,but not rHuIL—1 ,could enhance the proliferative response to CD3 McAb.These results have significances for understanding the expression of CD3 antigen and it's func-tions.