Study on coenzyme Q_(10) protecting from oxygen-derived free radical in orthotopic liver transplanta- tion in rats / 中华器官移植杂志

ABSTRACT

In this experiment we used the model of the orthotopic liver transplantation with three cuff technique in rats.In treated group,coenzyme Q_(10) was injected intravenously into donor rats before donor hepatectomy.At the 4th hour after transplant,the activity of superoxide dismu- tase (SOD) and the level of lipid peroxidation (LPO) both in the blood and in the liver tissue were measured,meanwhile,the specimens of the grafted liver tissue were sent for microscope and elec- tromicroscope studies.The results showed(1) The activity of SOD in treated group were higher than that in control group (P