Treatment of olfactory neuroblastoma with surgery plus irradiation——a report of 14 cases / 中国癌症杂志

ABSTRACT

Purpose:To evaluate the effects of surgery plus irradiation for olfactory neuroblastoma Methods:From January 1975 to February 1998 fourteen patients with olfactory neuroblastoma (kadish dassificationOne case in stage A, 8 in the Stage B, 5 in stage C) were resected and giver radiotherapy to an average dose of 6000 cGy to primary lesions.Results:Six of the 14 patients have been living for 2—24 years. 8 died (5 of recurrence and 3 of distant metastasis)in 6 months to 4 years after diagnosis.Conclusions: There is a high rate of pathologic misdiagnosis in olfactory neuroblastoma. Immunohistologic examination and electron microscopic study are benifitial for diagnosis. Surgery plus irradiation is a suitable method for olfactory neuroblastoma. Radiotherapy is able to reduce local recurrence after surgery and increase resectability rate as well as to control distant metastasis.