Expression and clinical significance of nm23-H_1 and nm23-H_2 in human breast cancer / 中国癌症杂志
China Oncology
;
(12)1998.
Article
in Chinese
| WPRIM
| ID: wpr-674777
ABSTRACT
Purpose:
To investigate the expression and clinical significance of nm23 H 1 and nm23 H 2 in human breast cancer.Methods:
A semi quantitative reverse transcription polymerase chain reaction was performed to detect the expression of nm23 H 1 and nm23 H 2 mRNA in thirty human breast cancer specimens. To evaluate the relationship between nm23 gene and breast cancer metastasis t test, F test and multivariate analysis were used.Results:
The nm23 H 1 mRNA level in primary breast cancer tissue with lymph node positive was lower than that with lymph node negative. The nm23 H 1 mRNA level in breast cancer with Ⅰ,Ⅱstage was higher than that with Ⅲ stage. Lymph node metastasis was the only parameter that was significantly correlated with the nm23 H 1 expression. There was no significant relation between nm23 H 2 and tumor size, lymph node status, TNM stage, hormone receptor and menopausal status.Conclusions:
nm23 H 1 mRNA show a significant inverse correlation with lymph node metastasis. nm23 H 1 appears to play a more important role than nm23 H 2 in breast cancer. nm23 H 1 mRNA expression may be a predictor of lymph node metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Oncology
Year:
1998
Type:
Article
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