Expression of TopoⅡ gene in human bladder cancer multidrug-resistant cells / 中国癌症杂志
China Oncology
; (12)2001.
Article
in Zh
| WPRIM
| ID: wpr-675009
Responsible library:
WPRO
ABSTRACT
Purpose:To study the expression of TopoⅡ gene in multidrug resistant cells of human bladder cancer. Methods:The degree of drug resistance was detected by MTT method ;the expression of TopoⅡ gene in cell lines BIU 87/ADM and BIU 87 was detected with reverse transcriptase polymerase chain reaction. Results:The cell lines BIU 87/ADM were 56.4 times more resistant to ADM than the cell lines BIU 87;the expression of TopoⅡ gene was poorly positive in BIU 87/ADM but strongly positive in BIU 87 cells. Conclusions: The decreased expression of TopoⅡ gene in BIU 87/ADM cells might contribute to the development of multidrug resistance of human bladder cancer.
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WPRIM
Language:
Zh
Journal:
China Oncology
Year:
2001
Type:
Article