Experimental study on inducing apoptosis of tumour cells by protamine inhibiting angiogenesis / 中国癌症杂志

ABSTRACT

Purpose:To study the therapeutic mechanism through inducing apoptosis of tumour by protamine inhibiting angiogenesis . Methods:The vascular density and apoptotic index(AI)in the tumour were investigated by immunohistological and Tunel(terminal deoxynucletidy1 transferase-mediated dU TP nick end-labelling) methods in animal tumour model with experimental treatment. Results:The vascular density of tumour was much lower in controls. Apoptosis appeard in the treated group and AI is (7.67?1.70)%. Conclusions:Protamine could reduce the vascular density of tumour very much and induce the apoptosis of tumour cells. The therapeutic effects were achieved by inhibiting angiogenesis and inducing apoptosis of tumour.