The relationship between glucose tolerance and coronary artery lesion in the patients with coronary heart disease / 中华内分泌代谢杂志

ABSTRACT

Objective To investigate the relationship between glucose tolerance change and the coronary artery lesion in the patients with coronary heart disease. Methods One hundred and ninety three patients with coronary artery disease were divided into 3 groups according to WHO(1985) and American Diabetes Association (1997) standard of diabetic diagnoses (1) normal glucose tolerance (NGT) group 122 cases; (2) impaired glucose tolerance (IGT) group 39 cases; (3) type 2 diabetes mellitus (DM) group 32 cases. All patients were examined by the coronary angiographic semiquantitative (CAG) and 75 g oral glucose tolerance test. Blood glucose, insulin, triglyceride (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL C) were determined. The coronary artery changes were analysed by CAG, and the severity of coronary artery stenosis was evaluated according to American Heart Association standard. The risk factors of coronary artery lesion were analysed by pluralism stepwiss regression analysis. Results The coronary multivessel changes and the severity of coronary artery stenosis and calcification were more frequent in IGT group than those in NGT group (66.5% vs 35.1%, 8.9?3.6 vs 6.5?3.9, 6.3?3.6 vs 3.9?4.1 respectively, P