Effect of cyclosporin A on prognosis of the abortion-prone murine model / 中国免疫学杂志

ABSTRACT

Objective:To study effect of cyclosporin A(CsA) on the prognosis of the abortion prone murine model.Methods:0,5,10,15 mg/kg CsA were injected intraperitoneally to CBA/J female mice at the fourth gestational day which mated to DBA/2 or BALB/c male mice as an abortion prone model and a successful pregnancy model respectively,thereafter the fetus resorption rate,weight of placenta and fetus were surveyed.Results:CsA could reduce the fetal resorption rate of pregnancy loss model significantly,meanwhile the weight of fetus and plancenta did not have notable alteration,but tendency of the weight increase exists.However,CsA did not affect the fetal resorption rate or the weight of fetus and placenta of the successful pregnancy model.Conclusion:CsA injected intraperitoneally at the early stage of pregnancy could reduce the fetal resorption rate of pregnancy loss model to that of normal pregnancy.The weight of fetus and plancenta appeared to have an increase tendency although non significantly.Therefore,CsA seems to be a potential medicine for protecting pregnancy from abortion.