Osteoporosis induced by orchiectomy in prostate cancer / 中华泌尿外科杂志

ABSTRACT

Objective To study osteoporosis in patients after orchiectomy for prostate cancer. Methods 64 patients were divided into two groups.In the first group,31 patients with prostate cancer treated by orchiectomy.The other 33 patients were taken as contrast(second group) which were benign prostate hyperplasia (BPH) treated by finasteride.BMD,X ray,serum testoterone and parameters of bone metabolism were measured both before and 6 months after treatment for both groups.Osteoporosis was defined according to WHO criteria. Results A significant reduction of BMD and serum testoterone were observed in the first group 6 months after orchiectomy ( P 0.05).All the patients in first group were classified as osteoporosis 6 months after orchiectomy. Conclusions It is suggested that androgen deprivation would induce osteoporosis which should be treated in early stage.