Relationship between cytokine gene polymorphisms and acute rejection after renal transplantation / 中华器官移植杂志

ABSTRACT

Objective To investigate the cytokine genotypes of the renal transplantation recipients with or without acute rejections.Methods The cytokine genotypes of peripheral blood TNF ?, TGF ? IL 6 and IFN ? in 89 kidney to allograft receipients were detected by using PCR method. According to the test, the occurrence of acute rejection was compared among the groups. Results TNF ? and IFN ? high producer genotype (-308 GA and AA) showed a correlation with the high incidence of acute rejection to the HLA DR mismatching recipients. Conclusion To detect the cytokines gene polymorphisms before operations can find the high risk kidney receipients who may suffer from the acute rejection. It's very helpful in guiding the individual use of immunosuppressants following the renal transplantation.