Oncologic Outcomes of Stage IIIA Colon Cancer for Different Chemotherapeutic Regimens
Journal of the Korean Society of Coloproctology
;
: 259-264, 2012.
Article
in English
| WPRIM
| ID: wpr-67521
ABSTRACT
PURPOSE:
Adjuvant chemotherapy is currently recommended for Stage IIIA colon cancers. This study aimed to elucidate the oncologic outcomes of Stage IIIA colon cancer according to the chemotherapeutic regimen based on a retrospective review.METHODS:
From 1995 to 2008, Stage IIIA colon cancer patients were identified from a prospectively maintained database at a single institution. Exclusion criteria were as follows rectal cancer, another malignancy other than colon cancer, no adjuvant chemotherapy and unknown chemotherapeutic regimen. One hundred thirty-one patients were enrolled in the study, and the clinicopathologic and the oncologic characteristics were analyzed. The number of males was 72, and the number of females was 59; the mean age was 59.5 years (range, 25 to 76 years), and the median follow-up period was 33 months (range, 2 to 127 months).RESULTS:
Of the 131 patients, fluorouracil/leucovorin (FL)/capecitabine chemotherapy was performed in 109 patients, and FOLFOX chemotherapy was performed in 22 patients. When the patients who received FL/capecitabine chemotherapy and the patients who received FOLFOX chemotherapy were compared, there was no significant difference in the clinicopathologic factors between the two groups. The 5-year overall survival and the 5-year disease-free survival were 97.2% and 94.5% in the FL/capecitabine patient group and 95.5% and 90.9% in the FOLFOX patient group, respectively, and no statistically significant differences were noted between the two groups.CONCLUSION:
Stage IIIA colon cancer showed good oncologic outcomes, and the chemotherapeutic regimen did not seem to affect the oncologic outcome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Rectal Neoplasms
/
Prospective Studies
/
Retrospective Studies
/
Follow-Up Studies
/
Chemotherapy, Adjuvant
/
Colon
/
Colonic Neoplasms
/
Disease-Free Survival
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of the Korean Society of Coloproctology
Year:
2012
Type:
Article
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