Expression of c-kit receptor in acute leukemia and its clinical significance / 中国癌症杂志

ABSTRACT

Purpose:To explore the expression of human c kit receptor protein (c kit R, CD117) in acute leukemia (AL). The focus of the study was put on the value of the expression of c kit R in diagnosis for acute non lymphoid leukemia (ANLL).Methods:Flow cytometry (FCM) was used to determine the expression of the transmembrane c kit R on mononeuclear cell in bone marrow in 24 patients with acute lymphoid leukemia (ALL) and 47 patients with acute non lymphoid leukemia (ANLL). Results:There was no significant difference between expression of c kit in healthy individuals and patients with ALL. The expression of c kit in patients with ANLL was significantly higher than that of healthy individuals and that of patients with ALL ( P