Genetic polymorphisms of p53 codon72 and the risk of gastric cancer-case-control study / 中国癌症杂志
China Oncology
;
(12)1998.
Article
in Chinese
| WPRIM
| ID: wpr-675255
ABSTRACT
Purpose:
To explore the relationship between genetic polymorphisms of p53 codon72 and the risk of gastric cancer.Methods:
A population based case control study was conducted in Taixing, Jiangsu Province, China, and 204 gastric cancer cases and 415 controls were collected.Results:
Distribution of Pro/Pro genotype in cancer cases was significantly higher than controls. The OR and 95%CI of Pro/Pro or Pro/Arg genotype was 1.5 (1.01~2.23) compared with Arg/Arg genotype. Pro/Pro or Pro/Arg genotype may interact with cigarette smoking, alcohol drinking, river water drinking and high salt food intake.Conclusions:
Pro genotype may be related with the risk of gastric cancer and may also interact with environmental risk factors to increase the risk of gastric cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
Chinese
Journal:
China Oncology
Year:
1998
Type:
Article
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