Expressions of VEGF, b-FGF,NOS_2 and NOS_3 in human non-small cell lung cancer and the relationship between them and tumor angiogenesis and lymph node metastasis / 中国癌症杂志

ABSTRACT

Purpose:To investigate the expression and distribution of VEGF, b FGF, NOS 2 and NOS 3 in human non small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis.Methods:The expression of VEGF, b FGF, NOS 2, NOS 3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (SP), and the relationship between them and many clinicopathological parameters was analyzed.Results:The positive expression of VEGF and b FGF was associated with intratumor microvessel density(IMVD), TNM stage and lymph node metastases of NSCLC, respectively( P