Expression of COX-2 and its significance in rectal familial adenomatous polyposis and rectal cancer tissues / 中国癌症杂志
China Oncology
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-675442
ABSTRACT
Purpose:
To study COX 2 protein expression and its significance in familial adenomatous polyposis (FAP) and rectal cancer tissues.Methods:
Flow cytometry was used to detect COX 2 protein expression in surgical specimens from 12 normal rectal mucosa tissues, 19 FAP tissues, 7 transformed FAP tissues and 36 rectal cancer tissues.Results:
The COX 2 protein expression was negative in the 12 normal rectal mucosa tissues ( FI=0.67?0.28). The COX 2 protein expression was positive in 18 (94.74%) of the 19 FAP tissues (FI=1.97?0.36),the 7(100%) transformed FAP tissues(FI=2.02?0.24) and the 36(100%) rectal cancer tissues (FI=2.14?0.31). The COX 2 protein and positive expression rates showed that there were obvious differences between normal rectal mucosa tissues and FAP tissues, transformed FAP tissues, rectal cancer tissues( P 0.05).Conclusions:
It is suggested that the detection of COX 2 protein expression can have important significance for predicting adenomatous polyposis carceration and chemo interfering carceration progress. [
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Oncology
Year:
2001
Type:
Article
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