Effects of chemotherapy on operation for lung cancer / 中国癌症杂志

ABSTRACT

Purpose:To investigate the effects of chemotherapy on the patient's operation for lung cancer.Methods:One hundred patients were randomized into two groups. ①Preoperative chemotherapy group, the patients accepted chemotherapy first, then underwent operation, 59 cases;②postoperative chemotherapy group, the patients accepted the chemotherapy after operation, 41 cases. Most of the patients accepted the MVP chemotherapy regimen (1-6 course). All patients underwent operation of lobectomy or pneumonectomy. During the operation, the change of thorax structure was observed. Some indexes, which include operation time, blood loss during operation and postoperative drainage volume of first day, were recorded. The data were analysed with SPSS software.Results:①It is indicated that preoperative chemotherapy induce thoracic tissue fibrosis, which include pleura, the tissue around tumor and lymph nodes. The tissue fibrosis of pulmonary artery was most notable, which increase the risk and difficulty of operation .The serious grade of tissue fibrossis was related to the courses of chemotherapy. ②The operation time of preoperative chemotherapy group was longer than that of postoperative chemotherapy group ( P 0 05).④There was no significant difference in postoperative drainage volume in the two groups.Conclusions:①Chemotherapy increases the patients′ operation risks for lung cancer;②Fibrosis is an underlying risk factor for blood loss, it is necessary to pay more attention to careful hemostasia during the operation. ③To decrease the risks of postoperative complication, sufficient interval after chemotherapy, preoperative preparation and proper management after operation are the key factors.