1H MR Spectroscopy in Parkinson's Disease and Progressive Supranuclear Palsy: Preliminary Study
Journal of the Korean Radiological Society
;
: 711-716, 1996.
Article
in Korean
| WPRIM
| ID: wpr-67574
ABSTRACT
PURPOSE:
To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiating idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios. MATERIALS ANDMETHODS:
Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of 135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions of interest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. ESULTS NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 +/-0.26 versus 1.45 +/-0.20, and 1.26 +/-.23 versus 1.38 +/-0.19, respectively p0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients.CONCLUSION:
NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSP group than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differential diagnosis of IPD and PSP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Putamen
/
Steam
/
Supranuclear Palsy, Progressive
/
Magnetic Resonance Spectroscopy
/
Lactic Acid
/
Corpus Striatum
/
Neurons
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
1996
Type:
Article
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