Influence of recipient cytokine gene polymorphisms on incidence of infection after renal transplantation / 中华器官移植杂志

ABSTRACT

Objective To explore the influence of renal allograft recipient cytokine and cytokine receptor gene polymorphisms on the infection after renal transplantation. Methods (1) 126 cases of cadaveric renal allograft recipients were divided into two groups according to the presence or Absence of infection in 6 months after renal transplantation infection group and un infection group. The distribution of 22 polymorphisms in 13 cytokines and cytokine receptors gene were compared between two groups as well as latent factors affecting the onset of infection. The production types of IL 10, TNF ?, TGF ?1 and IL 6 were analyzed; (2) All recipients were stratified into two conditions presence of rejection or Absence of rejection. Previous positive gene polymorphisms were compared between infection group and un infection group under two conditions. Results (1) The incidence of acute allograft rejection was significantly higher in infection group than in un infection group. In infection group, the genotype frequency of IL 1? 889 C/C, IL 1? 511 C/C, IL 1?+3962 C/T or T/T, and the higher production type frequency of TGF ?1 were significantly higher than those in un infection group. (2) In the recipients without acute rejection, the genotype frequency of IL 1? 511C/C was significantly higher in infection group than in un infection group; whereas in those with acute rejection, the genotype frequency of TGF ?1 (codon10 codon 25) CG/TG and frequency of TGF ?1 with high production were significantly higher than those in no infection group. Conclusion This study identified recipient genotype of IL 1? 889 C/C, IL 1? 511 C/C, TGF ?1(codon10 codon 25) CG/TG and higher production type of TGF ?1 gene as major risk factors for the onset of infection after renal transplantation as well as presence of acute allograft rejection, which might affect the action of these gene polymorphisms.