Effects of long-term excessive Iodine intake on the maternal-fetal thyroid hormone metabolism in mice / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-676246
ABSTRACT
Long-term excessive iodine intake resulted in an increased TT_4 level and a decreased TT_3 level in maternal serum,meanwhile,hepatic and renal type 1 deiodinase activity decreased dose-dependently.A significant reduction in type 2 deiodinase ( D2 ) activity of 12.5 d placenta was found in 3.0 mg/L or above groups.For 19.5 d uterus,D2 activity decreased and type 3 deiodinase activity increased.The results suggest that excessive iodine has an effect on the embryonic development by regulating maternal-fetal thyroid hormone metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2000
Type:
Article
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