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Two Cases of Interstitial Pneumonitis Caused by Rituximab Therapy
The Korean Journal of Internal Medicine ; : 183-186, 2006.
Article in English | WPRIM | ID: wpr-67633
ABSTRACT
Rituximab, a chimeric monoclonal antibody directed against CD20, has become a part of the standard therapy for patients with non-Hodgkin's lymphoma either in combination with other drugs or as a single agent. The CD20 antigen is expressed on 95% of B-cell lymphoma cells and normal B-cells but, is not found on precursor B-cells or stem cells. Rituximab is now approved for patients with diffuse large B-cell lymphoma when combined with standard CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or patients with follicular lymphoma who have failed first line chemotherapy. The monoclonal antibody is generally well tolerated. Most of the adverse events are infusion-associated, mild to moderate non-hematological toxicities. Severe respiratory adverse events have been infrequent. Here, we report two patients with non-Hodgkin's lymphoma in whom interstitial pneumonitis developed with rituximab therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Methylprednisolone / Prednisolone / Lung Diseases, Interstitial / Antibodies, Monoclonal / Antineoplastic Agents Limits: Aged / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Methylprednisolone / Prednisolone / Lung Diseases, Interstitial / Antibodies, Monoclonal / Antineoplastic Agents Limits: Aged / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2006 Type: Article