Role of angiotensinⅡin the changes of MMP-9 and TIMP-1 mRNA expressions in high glucose-induced mesangial cells of rat / 中华内分泌代谢杂志

ABSTRACT

High glucose stimulated angiotensinⅡ(ATⅡ) production in mesangial cells of rat.Both high glucose and ATⅡdecreased expressions of matrix metalloprotein-9 (MMP-9) mRNA and MMP-9/tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA ratio and increased TIMP-1 mRNA expression in mesangial cells of rat,which could be reversed by an ATⅡreceptor blocker,Saralasin.