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Effects of losartan and amlodipine on plasma leptin and adiponectin levels and insulin sensitivity in obese hypertensive patients / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12)1985.
Article in Chinese | WPRIM | ID: wpr-676352
ABSTRACT
Objective To observe the effects of losartan and amlodipine on blood pressure,plasma levels of leptin,adiponectin and norepinephrine (NE) and insulin sensitivity in obese hypertensive patients.Methods The levels of plasma leptin and adiponectin were determined by RIA and the plasma NE level was assayed by high- performance liquid chromatography.Insulin resistance index (HOMA-IR) was evaluated using the homeostasis model.Results Compared with basal levels,after 16-weeks' therapy,plasma leptin,HOMA-IR and body mass index were significantly decreased in losartan group [(35.6?18.5 vs 32.0?17.1)?g/L,P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 1985 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 1985 Type: Article