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Detection of mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma / 实用口腔医学杂志
Journal of Practical Stomatology ; (6)2001.
Article in Chinese | WPRIM | ID: wpr-676879
ABSTRACT

Objective:

To detect mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma(OSCC),and to explore the relationship between gene mutations and development of OSCC.

Methods:

Mutations of exons 5 and exons 8 of PTEN gene were detected by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP).

Results:

The whole sequences of exons 5 and exons 8 of PTEN gene of all cases of OSCC were expanded.There was no mutation in exons 5 and exons 8 of PTEN gene of all cases of OSCC.

Conclusion:

There is no mutation in exon 5 and exon 8 of PTEN gene in OSCC.This might show that there is no correlation between mutations in exon 5 and exon 8 of PTEN gene and the development of OSCC.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Journal of Practical Stomatology Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Journal of Practical Stomatology Year: 2001 Type: Article