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Effects of Perinatal Exposure to Low-dose Tributyltin on Development and Estrogen Level of Female Offspring Mice / 环境与健康杂志
Journal of Environment and Health ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-676888
ABSTRACT
Objective To explore the effects of perinatal exposure to low dose tributyltin (TBT) on development and estrogen level of female offspring KM mice.Methods The CL healthy adult pregnant KM mice were randomly divided into 4 groups,6 in each group,they were given doses of TBT (100,10 and 1 ?g/kg) by gavage from days 6 of gestation to the end of lactation,1 time each day,at a volume of 1 ml/kg.On postnatal day (PND) 49,10 female offspring mice were randomly selected in each group and killed after weighed and the blood was collected.The uterus and ovary were weighed for account of viscera coefficient.The concentrations of estrogen in serum were measured with radioimmunoassay.Results Compared with the control group the time of eye opening was significantly delayed and the vagina opening was significantly ahead in treatment groups (P0.05).The weight of ovary and its coefficient increased significantly in 10 ?g/kg group (P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Environment and Health Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Environment and Health Year: 2007 Type: Article