EFFECT OF LEVO-PRAZIQUANTEL ON THE EXPOSURE OF TEGUMENTAL SURFACE ANTIGEN OF SCHISTOSOMA JAPONICUM / 中国血吸虫病防治杂志

ABSTRACT

Mice infected with Schistosoma japonicum were treated with a single oral dose of levo-praziquantel 75mg/kg or racemic praziquantel 150mg/kg. 10min-7d after administration of the drugs, the infected mice were sacrificed and the parasites were studied. The tegumental antigen of the integral worms and of. the worm sections were tested by IFA.10-30 min after treatment more than 50% of the tegumental surface of adult worm showed weak and small fluorescent spots in treated groups. 1-6h after treatment, the sucker and extremity of adult worm showed brighter fluorescent spots. From 6h after treatment, there were very bright fluorescent spots on the whole worm surface. 3d after treatment, the fluorescent intensity was weaker than before, and there was no significant difference between the levo-praziquantel group and racemic praziquantel group in the exposure of tegumental surface antigen. The results demonstrated that levo-praziquantel, just like the racemic-praziquantel, could disturb the tegumental metabolic course of the schistosomes, caused tegumental damage and exposure of adult worm surface antigen.