The modulation effects of tumor necrosis factor on endothelial cells in their synthesis of tissue factor in vitro / 第三军医大学学报

ABSTRACT

Endothelial cells (EC) from human umbilical vein have been subcultured for 10 passages as identified with optical and electron microscopy.The modulation effects of recombinant human tumor necrosis factor (rHTNF and TNF) on the 1st to 3rd generation of ECs in their synthesizing tissue factor were studied.It was found that when rHTNF and ECs were cocultured to the 4th hour,the activity of the tissue factor synthesized by ECs was significantly elevated (P