Detection of hepatitis C virus RNA in bone marrow mononuclear cells by digoxin-labeled in situ hybridization / 中华传染病杂志
Chinese Journal of Infectious Diseases
;
(12)1997.
Article
in Chinese
| WPRIM
| ID: wpr-677090
ABSTRACT
To investigate HCV extrahepiatic infection and replication site as well as its relation with liver damage,bone-marrow mononuclear cells from 20 cases of nutreated chronic hepatitis C virus infect- ed patients were studied by digoxin-labeled in situ hybridization.Positive HCV RNA stained were de- tected in 18 of 20 cases (90%).Negative HCV RNA stained were not detected in any cases.The results suggested that there was HCV RNA in the bone-marrow of the patients with hepatitis C and bone-mar- row could be infected by HCV.But bone-marrow cell is not the HCV replication site.This study has some significance in HCV elucidating the pathogenicity of as well as the pathogenesis of chronic hepatitis C.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Infectious Diseases
Year:
1997
Type:
Article
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