Release of anticancer doxorubicin-hydroxypatite(DOX-HAP) complex in rabbit liver / 中国临床药理学与治疗学

ABSTRACT

Aim The release process of an anticancer agent, DOX_HAP in rabbit liver was observed.Methods DOX and DOX_HAP were separately injectoed into rabbit livers under the guide of B type ultrasound. Dox concentrations in plasma and liver tissue of the rabbits in both groups were measured by fluorescent stectrophotometer and compared. Results The concentration of complex could existed in the liver tissue about 5 d(1 000 ng?g-1) when it was given in a dose of 2 mg?g-1. At the 10 min the concentration in plasma would be reduced about 1/2 as compared with that in the control group. Conclusions The DOX_ HAP complex not only could increase and insist in an effective concentration of DOX at the local injecting area of liver tissue, but also reduce its concerntration in the plasma. Therefore, it could decrease the toxicity and side_effect of DOX.