Effect of glucocorticoid on the calmodulin mRNA of hypothalamus-pituitary-adrenal axis / 中国药理学通报

ABSTRACT

AIM To study the effect of glucocorticoid acetic acid cortisone on expression of CaM mRNA in hypothalamus pituitary adrenal axis (HPAA). METHODS Using reverse transcription polymerase chain reaction (RT PCR),the expression of CaM mRNA was measured in HPAA of rats which were injected with acetic acid cortisone. RESULTS Acetic acid cortisone induced the expression of CaM mRNA in hypothalamus and adrenal respectively, but it had no effect significantly in pituitary. CONCLUSION These data suggest that CaM mRNA plays important role in the modulation of GC in HPAA.