Mechanisms of action of protein kinase C in myocardial preconditioning / 中国药理学通报

ABSTRACT

PKC plays a pivotal role in the mechanism of myocardial preconditioning. After preconditioning, PKC is activated and translocated to membranes and cytoskeleton structures by multiple endogenous substances such as adenosine, calcium, etc. Recent studies imply that MAPK carries the signal from PKC to the mitochondria K ATP channel and thus protect the heart.