EFFECT OF MAGNESIUM SUPPLEMENTATION ON LIPID PEROXIDATION AND ANTIOXIDATIVE ENZYMES / 营养学报

ABSTRACT

Objective:The effect of magnesium on lipid peroxidation of endothelial cells induced by H 2O 2 and t bultyl hydroperoxide and subsequent alterations of extracellular superoxide dismutase(EC SOD) and cellular selenium dependent and selenium independent GSH Px were studied. Methods:The extent of cellular lipid peroxides was determined by measuring the formation of TBARS, EC SOD by the method of pyrogallol auto oxidation, and GSH Px by the method of DTNB. Results:The results showed that the formation of TBARS was significantly reduced in the group of H 2O 2+Mg 2+ at doses of 0.3, 0.6, 1.2,and 2.4 mmol/L compared to the group of H 2O 2(P