Protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibitor / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1986.
Article
in Zh
| WPRIM
| ID: wpr-677546
Responsible library:
WPRO
ABSTRACT
During ischemia, the intracellular acidosis stimulates the Na +/H + exchanger. The increase in intracellular sodium secondary to increased Na +/H + exchange is reversed through exchange for calcium, resulting in calcium overload of the cells and producing cell injury and necrosis. NHE1 inhibitors exert a protective effect on myocardium subject to ischemia and reperfusion via reduction of Na +/H + exchange, attenuation of intracellular calcium accumulation and other mechanisms.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article