THREE CASES OF PICK′S DISEASE:A CLINICAL AND PATHOLOGICAL ANALYSIS / 解放军医学杂志

ABSTRACT

Three cases of Pick's disease diagnosed by clinical observation, MRI, SPECT, PET and pathology were analysed. Compared with Alzheimer′s disease, Pick's disease consisted of the following features ①The changes in personality, judgement, affection and emotion, Kl?ver Bucy syndrome, progressive non fluent aphasia,and the defect of semantic memory were prominent in the early stage, but the disturbance of cognition and visuospatial ability were relatively late. ②Marked cerebral atrophy in the temporal pole was showed in MRI. ③Hypoperfusion and hypometabolism could be found in the frontal and / or temporal cortexes on SPECT or PET scans. It is important to understand the salient features for early diagnosis of Pick's disease in clinic.