Preparation and bioavailability study of calcitonin oral microparticle in rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-677604
ABSTRACT
Objective:
To prepare the calcitonin oral microparticle.Methods:
The oral delivery system of salmon calcitonin was made using diketopiperazine microparticles as carrier by the method of sole solifification. The parameters including the shape of microparticle,dissolving in vitro , the effect of reducing bleed calcium and bioavailability etc . were observed.Results:
The diameter of the microparticles was 1 3 ?m, and the drug concentration was 0.42%. The rate of encapsulating was 91.1%. The drug did not release within 2 h in artificial gastric fluid and completely released in artificial intestinal fluid within 6 h. The microparticles had obvious effect of reducing bleed calcium 3 h after it was taken, the effect lasted for 12 h.Conclusion:
The microparticles of salmon calcitonin release slowly and have better effects of reducing bleed calcium by oral delivery system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
1999
Type:
Article
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