Protective effects of amitriptyline on glutamate-induced neurotoxicity in cerebral neuronal cultures / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-677652
ABSTRACT
AIM:
To study the protective effects of amitriptyline (Ami) on glutamate induced neurotoxicity in cultured rat cerebral cortical neurons.METHODS:
Cortical neurons of fetal rat were cultured in vitro. The protective effects of Ami on glutamate induced neurotoxicity were observed.RESULTS:
Exposure of rat fetus cerebral cells to Glu medium developed a neurotoxicity, expressed in the increase of LDH, NO and MDA, and the decrease of activity of SOD,as well as the development of morphological injury. Ami (10 -6 ,10 -7 , 10 -8 mol?L -1 ) significantly protected neurons against above demage.CONCLUSION:
Ami can prevent rat cerebral neurons injury from the toxicity of Glu.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2000
Type:
Article
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