Effects of 9-(4-Ethoxycarboxylyphenoxy)-6,7-dimethoxy-1,2,3,4-tetrahydro acridine on learning and memory ability in mice / 中国临床药理学与治疗学

ABSTRACT

AIM: To study the effects of 9 (4 Ethoxycarboxylyphenoxy) 6,7 dimethoxy 1,2,3,4 tetrahydro acridine (EDT) on learning and memory abilities. METHODS: The step down test and Y maze test were adopted in this study. RESULTS: EDT ( 2.5 , 5, 10 mg?kg -1 , ig? 5 d ) dose dependently improved the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO 2 and alcohol in mice. CONCLUSION: EDT can improve learning and mermory ability in mice.