Epidermal growth factor prevents bacterial translocation in rats with acute pancreatitis / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1981.
Article
in Chinese
| WPRIM
| ID: wpr-677687
ABSTRACT
Objective:
To evaluate the protective effect of epidermal growth factor (EGF) on intestinal barrier functionin rats with acute pancreatitis.Methods:
Thirty-two male SD rats received injection of sodium taurocholate solution(3. 5 mg?L-1) into the pancreatic duct were randomly divided into control group (n=16) and treatment group (n=16). Animals incontrol group received total parenteral nutrition (TPN), animals in treatment group were fed on the same TPN formula ascontrol group and injections of EGF at a dose of 0. 2 mg' kg l' day--'. Rats were sacrificed on d 1 and d 5 of TPN. Concen-tration of xylose and fluorescein isothiocyanate (FITC)-dextran in superior mesenteric vein (SMV), protein and DNA contentin je junal mucosa were determined. Samples from SMV, mesenteric lymph nodes, pancreas, liver, spleen were harvested forcultures.Results:
FITC-dextran concentration in treatment group was significantly lower than in control group [(3. 4?0. 7)vs (7. 5?0. 9) mg. L-1, P<0. 0l]. Protein and DNA content in je junal mucosa in treatment group were significantly higherthan in control group [(2. 65?0. 23) vs (1. 12?0. 18) mg? cm-1, (0. 25?0. 07) vs (0. 12?0. 04) mg?cm-1, P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
1981
Type:
Article
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