Efficacy and safety of sibutramine in treatment of patients with overweight and simple obesity / 第二军医大学学报

ABSTRACT

Objective: To evaluate the efficacy and safety of sibutramine,an anti obesity drug, in patients with overweight and simple obesity. Methods: Forty six patients with overweight and simple obesity were randomly assigned to sibutramine or placebo group according to the rule double blind. Results: After a 2 week wash out followed by a 24 week treatment periods, body weight, BMI, waistline and hip of sibutramine group decreased significantly compared with placebo group. The effect was significant at week 4 and advanced at week 8. In sibutramine and placebo group, the total effective rates were 81.82% and 16.67% respectively. The incidence of total adverse effects (thirsty, constipation, headache, agrypnin and so on) in sibutramine group was 27.27% and 11.11% in placebo group. Conclusion: The short term obeservation shows that sibutramine is an effective and safe anti obesity drug in overweight and simple obesity treatment, and the patients compliance is good.