Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
The Korean Journal of Internal Medicine
;
: 722-730, 2017.
Article
in English
| WPRIM
| ID: wpr-67784
ABSTRACT
BACKGROUND/AIMS:
Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.METHODS:
We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis.RESULTS:
A total of 32 patients were analyzed (male to female ratio 1913, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort.CONCLUSIONS:
In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Medical Records
/
Cohort Studies
/
Follow-Up Studies
/
Treatment Outcome
/
Hematopoietic Stem Cell Transplantation
/
Hypoalbuminemia
/
Diagnosis
/
Azotemia
/
Hypercalcemia
/
Anemia
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2017
Type:
Article
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