EFFECTS OF 2?-(3-HYDROXYPROPOXY)-CALCITRIOL ON BONE MASS AND STRENGTH AND BONE METABOLISM IN OVARIECTOMIZED MICE / 营养学报

ABSTRACT

Objective: To compare the effects of synthetic 2 ?(3 hydroxypropoxy) calcitriol(ED 71) with 17 ? Estrodiol(E 2) on bone mass, strength and metabolism in ovariectomized(OVX) mice. Methods: 40 female Kunming mice, average 35 g, were randomly divided into 4 groups OVX group, Sham group, ED 71 group and E 2 group. The latter two groups were also ovariectomized and given ED 71 at 0.4 ?g/(kg?d) and E 2 at 30 ?g/(kg?d) respectively for 6 w. Bone mineral density(BMD), bone mineral content(BMC), bone strength and bone histomorphometric parameters were measured. Results: Compared with OVX mice, in ED 71 and E 2 group, femoral BMD and BMC increased respectively by 3.8%, 5.9% and 3.2%,5.7%; maximum load of femur increased respectively 18.7% and 16%; trabecular bone volume of lumbar vertebra increased respectively 10.6% and 16.1 and serum alkaline phosphatase decreased respectively by 58% and 37%. Conclusion: ED 71 significantly increased BMD, BMC and bone strengh and significantly inhibited bone turnover in OVX mice. Also ED 71 does not induce uterus proliferation.