STUDY ON ANTIOXIDATIVE AND ANTITUMOR EFFECT OF SELENIUM CONTAINING POLYSACCHARIDE IN GANODERMA LUCIDUM IN MICE / 营养学报

ABSTRACT

Objective: To investigate the effects of selenium containing polysaccharide from Ganoderma lucidum on SOD, GSH Px activity, MDA content in blood and liver and anti tumor effect in tumor bearing mice, and relationship between antioxidative and anti tumor effect. Methods: The tumor bearing BALB c mice were injected with 2.5 g/L? 5.0 g/L and 10.0 g/L SeGLP 1 respectively for 14 days. Weight of tumor, both SOD and GSH Px activities and MDA content of blood and liver were determined. Results: SeGLP 1 could significantly inhibit the growth of Hca f, maximal inhibition rate was 44%, SeGLP 1 significantly increased SOD, GSH Px activity, decreased MDA content of blood and liver in tumor bearing mice. Conclusion: The anti tumor effect of SeGLP 1 may be due to enhanced antioxidative capacity in tumor bearing mice.