Low dose transdermal scopolamine increases cardiac vagal tone in patients with acute myocardial infarction / 中国临床药理学与治疗学

ABSTRACT

AIM: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients with acute myocardial infarction. METHODS: A random, double blind, and placebo contrast trial was performed. Measures of heart rate variability (HRV) in patients given drugs or placebo were obtained by electrocardiograph and digital 24 h Holter recording before and after treatment. Baroreflex sensitivity (BRS) was performed using the phenylephrine method. RESULTS: Patients of acute myocardial infarction with transdermal scopolamine showed a significant increase in HRV time domain parameters and BRS after treatment (P