Reverse effect of losartan on myocardial fibrosis and left ventricular hypertrophy in treatment of essential hypertensive patients / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2002.
Article
in Chinese
| WPRIM
| ID: wpr-677964
ABSTRACT
AIM:
To investigate the effects of losartan on myocardial fibrosis and left ventricular hypertrophy in hypertensive patients.METHODS:
35 essential hypertensive patients with left ventricular hypertrophy were treated with losartan 50-100 mg for 6 mon. Before and after the treatment, serum procollagen typeⅢ (PCⅢ), laminin (LN), and hyaluronic acid (HA) were measured by radioimmunoassay; and left ventricular mass index (LVMI) was determined with ultrasonic cardiogram.RESULTS:
After treatment with losartan the serum levels of PCⅢ, LN, HA, and LVMI were all decreased (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2002
Type:
Article
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