The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke
Journal of the Korean Neurological Association
;
: 210-214, 2006.
Article
in Korean
| WPRIM
| ID: wpr-67799
ABSTRACT
BACKGROUND:
The purpose of this study was to evaluate the time course of PAC-1 and the P-selectin expression after the initiation of antiplatelets in acute ischemic stroke.METHODS:
We serially measured PAC-1 and the P-selectin expression level using flow cytometry immediately before and at one day, seven days, and one month after starting antiplatelets in 25 patients with acute cerebral infarctions.RESULTS:
The P-selectin expression increased initially (p<0.05) and then from the seventh day, it began to decrease continually (post-hoc analysis, p<0.05). However, the PAC-1 expression did not reveal significant alterations during the follow-up period of one month.CONCLUSIONS:
Although the P-selectin expression rapidly declined, the PAC-1 expression remained elevated for one month. Our results suggest that the P-selectin may be useful in monitoring platelet inhibition during the early period after cerebral infarction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Platelets
/
Cerebral Infarction
/
Follow-Up Studies
/
P-Selectin
/
Stroke
/
Flow Cytometry
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2006
Type:
Article
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