Effect of H_2O_2 on transient outword potassium current in the cultured rat hippocampal neurons / 中国药理学通报

ABSTRACT

AIM To study the effects of H 2O 2 on transient outward potassium current METHODS Whole cell patch clamp technique was used to record changes of I A in the cultured rat hippocampal neurons RESULTS After exposure to 30 ?mol?L -1 H 2O 2 for 12 h (1) decreased I A current density from (53 8?15 8) PA?PF -1 to (18 5?6 2) PA?PF -1 ( n=10,P