Biological functions of dipeptide transports in intestinal epithelial cells and development / 肠外与肠内营养

ABSTRACT

Transport of protein in the form of small peptides(di/tripeptides) across the small intestinal wall is a major route of dietary proteins absorption.The H + coupled dipeptide transporter,PepT1,located in the intestine and the kidney,plays an important role in the absorption of di/tripeptide;in addition,it mediates the intestinal absorption of ? lactam antibiotics,angiotensin converting enzyme inhibitors,and other peptide like drugs.The human intestinal cell line Caco 2 is an in vitro model.The dipeptide transporters normally found in the small intestine are present in Caco 2 cells.Caco 2 cells spontaneously differentiate in culture to polar cells possessing microvilli and enterocytic properties.These cells have been evaluated in detail as a model to study both transcellular and paracellular transport of nutrients and drugs in the gut.