A study on the human oral squamous carcinoma cell apoptosis induced by arsenic trioxide in vitro / 第三军医大学学报
Journal of Third Military Medical University
;
(24)1988.
Article
in Chinese
| WPRIM
| ID: wpr-678198
ABSTRACT
Objective To investigate the biological effects of As 2O 3 and its mechanism on human oral squamous carcinoma cell line in vitro . Methods The effects of As 2O 3 on Tca8113 cell line were investigated in vitro with morphological method, MTT, clone forming, DNA ladder, TUNEL assay and flow cytometry(FCM). Results As 2O 3 had marked suppressive effect on the growth of Tca8113 cell line. The growth suppression rate of the Tca8113 cells was 76.3% shown by MTT. DNA ladder, TUNEL and FCM showed As 2O 3 could induce the apoptosis of Tca8113 which might be related to cell cycle arrest shown by FCM. Conclusion As 2O 3 can inhibit the growth and induce the apoptosis of oral squamous carcinoma cell in vitro .
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
1988
Type:
Article
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